Follicular helper T cells (Tfh cells,
shown in blue) play a crucial role in the maturation of antibody-producing B
cells (shown in green). Activated B cells give rise germinal centers (shown in
red), where mature B cells proliferate and produce highly specific antibodies
against pathogens. Top left: normal germinal center in a mouse tonsil. All
others: Germinal centers fail to form when the interaction between ICOS and
TBK1 is interrupted. Credit: Dr. Kok-Fai Kong at La Jolla Institute for Allergy
and Immunology and Nature Immunology
Follicular
helper T cells (Tfh cells), a rare type of T cells, are indispensable for the
maturation of antibody-producing B cells. They promote the proliferation of B
cells that produce highly selective antibodies against invading pathogens while
weeding out those that generate potentially harmful ones. In their latest
study, researchers at La Jolla Institute for Allergy and Immunology identified
a key signal that drives the commitment of immature Tfh cells into fully functional
Tfh cells and thus driving the step-by-step process that results in a precisely
tailored and effective immune response.














